Science annotation · annotations/sa-010

A single psychedelic session can produce lasting psychological change persisting for months or years, not merely temporary state alteration.

Education, not medical advice. Drafts and study material from an independent research library. Citations on this page were checked on Oct 13, 2026; claims in the body text and organizational sources are still under review. What was checked.

Confirmed

A single psychedelic session can produce lasting psychological change persisting for months or years, not merely temporary state alteration.

Claim source
LSD: My Problem Child, Chapter 7
Current evidence · confidence: high
Shao et al. (Neuron, 2021): single psilocybin dose produces rapid and persistent dendritic spine growth in frontal cortex lasting at least 4 weeks in mice. MacLean et al. (Journal of Psychopharmacology, 2011): single psilocybin session produced lasting increases in the 'openness to experience' personality trait at 14-month follow-up, a trait normally stable after age 30. Griffiths et al. (Journal of Psychopharmacology, 2016): significant anxiety reduction in end-of-life cancer patients persisting 6+ months after one session.
Citation
Shao et al., Neuron (2021); MacLean et al., J Psychopharmacol (2011)

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What the Clinical Record Actually Showed: LSD Therapy 1947-1968, the editorial draft this item belongs with
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