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Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex

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Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex

Confirmed recorded as “Confirmed in Mice” Food of the Gods

Shao et al. (Yale, Neuron 2021): single psilocybin dose produces dendritic spine growth detectable at least one month later. Zhao et al. (Journal of Psychopharmacology, 2024) reported related plasticity effects in mice. Jiang et al. (Cell, 2026; online December 2025) reported large-scale cortical network rewiring in mice. These are animal findings; spine growth in the human brain after psilocybin has not been measured directly.

Shao et al., Neuron (2021); Zhao et al. (2024); Jiang et al., Cell (2026); Zhao et al., J Psychopharmacol (2024)