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The brain functions primarily as a reducing valve, filtering most of what could be perceived

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The brain functions primarily as a reducing valve, filtering most of what could be perceived

Partially Confirmed recorded as “Supported as a Model, Not Proven” The Doors of Perception

The REBUS model (Carhart-Harris & Friston, 2019) formalizes this as 'precision weighting of top-down priors.' Early fMRI work found reduced default mode network activity under psilocybin (Carhart-Harris et al., PNAS, 2012), though later studies have reported mixed patterns. Huxley's 1954 metaphor fits predictive coding models well; the models themselves are still being tested.

Huxley, The Doors of Perception (1954) / Carhart-Harris & Friston (2019)