Science annotation · annotations/sa-007

Lasting neuroplasticity from psychedelic exposure: the La Chorrera experience permanently altered the McKenna brothers' neural architecture.

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Partially Confirmed

Lasting neuroplasticity from psychedelic exposure: the La Chorrera experience permanently altered the McKenna brothers' neural architecture.

Claim source
True Hallucinations, aftermath chapters
Current evidence · confidence: medium
CONFIRMED: Psilocybin promotes dendritic spine growth persisting at least one month after a single exposure (Shao et al. 2021). Whether the specific changes at La Chorrera constituted lasting neuroplasticity in the therapeutic sense is not determinable. Whether these are attributable to the substances specifically, the experience, or the passage of time through a significant life event is not separable.
Citation
Shao et al. (2021); Nichols (2016)