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What does psilocybin do to dendritic spines?

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QuestionAnswerLevel
What does psilocybin do to dendritic spines?
neuroplasticity
Psilocybin promotes dendritic spine growth in mouse frontal cortex, with the effect persisting for at least one month after a single dose. This is distinct from the acute 5-HT2A mechanism and involves intracellular receptor signaling. The neuroplasticity finding is one of the most significant recent developments in psychedelic neuroscience and may explain lasting therapeutic effects.
intermediate