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What is the Default Mode Network and what do psychedelics do to it?
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| Question | Answer | Level |
|---|---|---|
What is the Default Mode Network and what do psychedelics do to it? mechanism | The DMN is a set of brain regions active during self-referential thought, mind-wandering, and autobiographical memory. Hyperactivity is associated with depression and rumination. Psychedelics suppress DMN connectivity, particularly the medial prefrontal cortex and posterior cingulate, which correlates with ego dissolution and may explain anti-depressant effects by interrupting negative rumination loops. Nichols (2016); Carhart-Harris et al. (multiple; no specific paper named) [Source not found; under review] | intermediate |
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