Flashcard · flashcards/fc-002
What is functional selectivity at the 5-HT2A receptor and why does it matter therapeutically?
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| Question | Answer | Level |
|---|---|---|
What is functional selectivity at the 5-HT2A receptor and why does it matter therapeutically? mechanism | The 5-HT2A receptor can activate two different downstream pathways: Gq protein (associated with psychedelic effects) and β-arrestin (associated with non-hallucinogenic effects). Drugs that selectively activate one pathway produce different effects, non-hallucinogenic 5-HT2A agonists (e.g., tabernanthalog) may produce therapeutic benefits without the psychedelic experience. This is the basis for second-generation psychedelic drug development. | advanced |
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